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Article

Evolutionarily conserved Tbx5 – Wnt2/2b pathway orchestrates cardiopulmonary development

23 Oct 2018

Abstract excerpt

Codevelopment of the lungs and heart underlies key evolutionary innovations in the transition to terrestrial life. Cardiac specializations that support pulmonary circulation, including the atrial septum, are generated by second heart field (SHF) cardiopulmonary progenitors (CPPs). It has been presumed that transcription factors required in the SHF for cardiac septation, e.g., Tbx5 , directly drive a cardiac...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30352852
DOI: 10.1073/pnas.1811624115

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