Article

Nanoscale CaV channel reorganization links α-synuclein pathology to calcium-dependent transcriptional dysregulation

2026-05-05

Abstract excerpt

Disrupted calcium (Ca 2+ ) homeostasis is a hallmark of neurodegenerative diseases, yet the mechanisms driving excessive Ca 2+ entry at the neuronal plasma membrane remain poorly understood. Here, we show that α-synuclein pre-formed fibrils trigger a reorganization of voltage-gated calcium (Ca V ) channels in cultured mouse cortical neurons, increasing their clustering at the soma and dendrites. We find that α-...

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Literature Corpus work: c596cca4-1217-5435-996c-6b34e71b5ca3
DOI: 10.64898/2026.05.01.719272

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