Article
Polymorphic cis- and trans-regulation of human gene expression.
PLoS biology - 14 Sept 2010
Cheung Vivian G, Nayak Renuka R, Wang Isabel Xiaorong, Elwyn Susannah, Cousins Sarah M, Morley Michael, Spielman Richard S
Abstract excerpt
Expression levels of human genes vary extensively among individuals. This variation facilitates analyses of expression levels as quantitative phenotypes in genetic studies where the entire genome can be scanned for regulators without prior knowledge of the regulatory mechanisms, thus enabling the identification of unknown regulatory relationships. Here, we carried out such genetic analyses with a large sample...
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