Purinergic signaling during macrophage differentiation results in M2 alternative activated macrophages.

doi:10.1189/jlb.1A0514-267RR

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Article

Purinergic signaling during macrophage differentiation results in M2 alternative activated macrophages.

Journal of leukocyte biology - 1 Feb 2016

Barberà-Cremades Maria, Baroja-Mazo Alberto, Pelegrín Pablo

Abstract excerpt

Macrophages represent a highly heterogenic cell population of the innate immune system, with important roles in the initiation and resolution of the inflammatory response. Purinergic signaling regulates both M1 and M2 macrophage function at different levels by controlling the secretion of cytokines, phagocytosis, and the production of reactive oxygen species. We found that extracellular nucleotides arrest...

Topics

Adenine
Adenine Nucleotides
Animals
Cell Cycle
Cell Division
Cells, Cultured
Gene Expression Regulation
Inflammation
Interferon-gamma
Interleukin-4
Lectins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lipopolysaccharides

Macrophage Activation

Macrophages

Mice

Mice, Inbred C57BL

Mice, Knockout

Myelopoiesis

Source

Open in PubMed

Identifiers

PMID: 26382298
DOI: 10.1189/jlb.1A0514-267RR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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