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Article

Phenotypic activation and pharmacological outcomes of spontaneously differentiated human monocyte-derived macrophages.

Immunobiology - 1 May 2015

Tedesco Serena, Bolego Chiara, Toniolo Alice, Nassi Alberto, Fadini Gian Paolo, Locati Massimo, Cignarella Andrea

Abstract excerpt

Macrophage activation has been observed in vivo under physiological and pathological conditions, and may represent an attractive target for pharmacological modulation. This study tested the hypothesis that human blood-derived macrophages generated in vitro in the absence of specific macrophage growth factors respond flexibly to activation stimuli and pharmacological treatment. Monocytes were differentiated to...

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PMID: 25582402
DOI: 10.1016/j.imbio.2014.12.008

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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