TRIM8 Inhibits Breast Cancer Proliferation by Regulating Estrogen Signaling

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Breast cancer (BC) ranks first in female malignancies wordwide, 70% of which are estrogen receptor alpha (ERα) positive. Endocrine treatment, such as tamoxifen, is primary adjuvant therapy for patients with ER-positive BC, while some of them can develop acquired resistance during long-time treatment. Thus, further research on estrogen signaling is of significanc...

Topics

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• Breast Neoplasms
• Cancer Mechanisms and Therapy
• Cytokine Signaling Pathways and Interactions
• Gene Expression Regulation, Neoplastic
• Gene Knockdown Techniques
• interferon and immune responses
• Peptidase Inhibition and Analysis
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

c56513d4-fd68-5905-92cc-640c496d48e8

DOI

10.21203/rs.3.rs-42521/v1