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Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53

14 Oct 2021

Abstract excerpt

Breast cancer is the most common cancer in the world. Relapse and metastasis are important factors endangering the life of breast cancer patients, but the mechanism is still unclear. The stabilization of p53 is essential for preventing carcinogenesis, and ubiquitination is one of the main ways to regulate the stability of p53. Tripartite motif-containing 31 (TRIM31) is a new member of the TRIM family and...

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PMID: 34650049
DOI: 10.1038/s41419-021-04208-3

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