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Decreased expression of TRIM21 indicates unfavorable outcome and promotes cell growth in breast cancer

1 Sept 2018

Abstract excerpt

BACKGROUND: Tripartite motif-containing protein 21 (TRIM21), an E3 ubiquitin ligase, has been implicated in autoimmune diseases. Dysregulation of TRIM21 contributes to the progression of human malignancies, but its role and clinical significance in breast cancer remain unclear. METHODS: The expression of TRIM21 was examined by quantitative real-time PCR, Western blot, and immunohistochemistry. The role of TRIM21...

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Cancer Mechanisms and Therapy
interferon and immune responses
Viral-associated cancers and disorders

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30288100
DOI: 10.2147/cmar.s175470

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