Article

TRIM45 Suppresses Breast Cancer Progression by Regulating Nrf2/Keap1 Pathway through Degradation of p62

2026-04-20

Abstract excerpt

<title>Abstract</title> <p>Overcoming oxidative stress is a critical mechanism by which breast cancer cells sustain malignant progression and therapeutic resistance. However, the specific regulatory networks governing this adaptive response remain incompletely understood. Here, we demonstrate that TRIM45, a tumor-suppressive E3 ubiquitin ligase, acts as a key negative regulator of the antioxidant defense system i...

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Literature Corpus work: 703f0ede-20d9-50ac-9cb6-de6b3a114332
DOI: 10.21203/rs.3.rs-9167161/v1

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