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Article

TRIM29 functions as a tumor suppressor in nontumorigenic breast cells and invasive ER+ breast cancer.

The American journal of pathology - 1 Feb 2012

Liu Jin, Welm Bryan, Boucher Ken M, Ebbert Mark T W, Bernard Philip S

Abstract excerpt

Tripartite motif-containing 29 (TRIM29) is a member of the TRIM protein family that has been implicated in hematologic and solid tumor cancers. We found that TRIM29 functions as a tumor suppressor in both the nontumorigenic MCF10A [estrogen receptor (ER)-/TRIM29+] breast cell line and the invasive MCF7 (ER+/TRIM29-) breast cell line. Silencing TRIM29 in MCF10A cells resulted in preneoplastic changes that included...

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Topics

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Share to Breast Neoplasms
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockdown Techniques

Share to Gene Silencing

Share to Genes, Tumor Suppressor

Share to Receptors, Estrogen

Share to RNA, Small Interfering

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22138580
DOI: 10.1016/j.ajpath.2011.10.020
PMCID: PMC5691328

Genes

TRIM29
FOS
GREB1
TFF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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