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Deconstructing sarcomeric structure–function relations in titin-BioID knock-in mice

19 Jun 2020

Abstract excerpt

Proximity proteomics has greatly advanced the analysis of native protein complexes and subcellular structures in culture, but has not been amenable to study development and disease in vivo. Here, we have generated a knock-in mouse with the biotin ligase (BioID) inserted at titin's Z-disc region to identify protein networks that connect the sarcomere to signal transduction and metabolism. Our census of the...

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PMID: 32561764
DOI: 10.1038/s41467-020-16929-8

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