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<i>In vivo</i> Protein Footprinting Reveals the Dynamic Conformational Changes of Proteome of Multiple Tissues in Progressing Alzheimer’s Disease

2023-05-30

Abstract excerpt

Numerous studies have investigated changes in protein expression at the system level using proteomic mass spectrometry, but only recently have studies explored the structure of proteins at the proteome level. We developed covalent protein painting (CPP), a protein footprinting method that quantitatively labels exposed lysine, and have now extended the method to whole intact animals to measure surface accessibility...

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Literature Corpus work
420ec746-1684-5070-9e39-a94674678aa7
DOI
10.1101/2023.05.29.542496
Open publication

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<i>In vivo</i> Protein Footprinting Reveals the Dynamic Conformational Changes of Proteome of Multiple Tissues in Progressing Alzheimer’s DiseaseDOI 10.1101/2023.05.29.542496
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