Article
A multicentre study of antifungal susceptibility patterns among 350 Candida auris isolates (2009-17) in India: role of the ERG11 and FKS1 genes in azole and echinocandin resistance.
The Journal of antimicrobial chemotherapy - 1 Apr 2018
Chowdhary Anuradha, Prakash Anupam, Sharma Cheshta, Kordalewska Milena, Kumar Anil, Sarma Smita, Tarai Bansidhar, Singh Ashutosh, Upadhyaya Gargi, Upadhyay Shalini, Yadav Priyanka, Singh Pradeep K, Khillan Vikas, Sachdeva Neelam, Perlin David S, Meis Jacques F
Abstract excerpt
Background: Candida auris has emerged globally as an MDR nosocomial pathogen in ICU patients. Objectives: We studied the antifungal susceptibility of C. auris isolates (n = 350) from 10 hospitals in India collected over a period of 8 years. To investigate azole resistance, ERG11 gene sequencing and expression profiling was conducted. In addition, echinocandin resistance linked to mutations in the C. auris FKS1...
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