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Article

Impact of FKS1 Genotype on Echinocandin In Vitro Susceptibility in Candida auris and In Vivo Response in a Murine Model of Infection.

Antimicrobial agents and chemotherapy - 18 Jan 2022

Sharma Dipti, Paul Raees A, Rudramurthy Shivaprakash M, Kashyap Nisha, Bhattacharya Sanjay, Soman Rajeev, Shankarnarayan Shamanth A, Chavan Dipali, Singh Shreya, Das Parijit, Kaur Harsimran, Ghosh Anup K, Prasad Rajendra, Sanyal Kaustuv, Chakrabarti Arunaloke

Abstract excerpt

Echinocandins are frontline antifungal agents in the management of invasive infections due to multidrug resistant Candida auris. The study aimed to evaluate echinocandin resistance in C. auris isolates of multicentric origin, identify the resistance mechanism, and analyze the pharmacodynamic response to caspofungin in a neutropenic mouse model of infection. A total of 199 C. auris isolates originating from 30...

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Identifiers

PMID: 34780273
DOI: 10.1128/AAC.01652-21
PMCID: PMC8765266

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Impact of FKS1 Genotype on Echinocandin In Vitro Susceptibility in Candida auris and In Vivo Response in a Murine Model of Infection.PMID 34780273Read ↗

Echinocandin Resistance in Candida auris Occurs in the Murine Gastrointestinal Tract Due to FKS1 Mutations.Semantic proximity Read ↗

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