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The human leukemic fusion protein MLL-AF4 promotes autophagy and cell death in the fat body of <i>Drosophila melanogaster</i>

2026-07-01

Abstract excerpt

MLL-rearranged (MLLr) leukemia is an aggressive form of acute leukemia driven by chromosomal translocations fusing MLL with one of more than 100 partner genes, most commonly AF4. We previously showed that expression of the human MLL-AF4 fusion protein in the larval hematopoietic system of Drosophila melanogaster promotes hyperproliferation. Here, we report that the same oncogene elicits a strikingly opposite resp...

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Literature Corpus work
c551222d-edc0-5695-9f2c-1f2994aaae09
DOI
10.64898/2026.07.01.735327
Open publication

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The human leukemic fusion protein MLL-AF4 promotes autophagy and cell death in the fat body of <i>Drosophila melanogaster</i>DOI 10.64898/2026.07.01.735327
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