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LIN28A-Dependent Kinome and Phosphoproteome Reprogramming Promotes Imatinib Resistance

2025-05-30

Abstract excerpt

<h4>ABSTRACT</h4> Chronic myeloid leukemia (CML) resistance to BCR-ABL tyrosine kinase inhibitors (TKIs) can arise from ABL kinase domain mutations, BCR-ABL fusion gene amplification, or kinase-independent mechanisms. To investigate imatinib-resistance, we performed quantitative mass spectrometry comparing the proteome and phosphoproteome of K562 cells (a standard CML model) and ImR cells, an imatinib-resistant K...

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Literature Corpus work
9909376a-e263-57bc-bed7-5a2f5f8a71da
DOI
10.1101/2025.05.30.652226
Open publication

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LIN28A-Dependent Kinome and Phosphoproteome Reprogramming Promotes Imatinib ResistanceDOI 10.1101/2025.05.30.652226
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