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MLL fusion-driven activation of<i>CDK6</i>potentiates proliferation in<i>MLL-</i>rearranged infant ALL

13 Jan 2014

Abstract excerpt

Acute lymphoblastic leukemia in infants (< 1 year-of-age) is characterized by a high incidence of MLL rearrangements. Recently, direct targets of the MLL fusion protein have been identified. However, functional validation of the identified targets remained unacknowledged. In this study, we identify CDK6 as a direct target of the MLL fusion protein and an important player in the proliferation advantage of...

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PMID: 24736461
DOI: 10.4161/cc.27757

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