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Article

Oncogenic FLT3-ITD supports autophagy via ATF4 in acute myeloid leukemia.

Oncogene - 8 Feb 2018

Heydt Q, Larrue C, Saland E, Bertoli S, Sarry J-E, Besson A, Manenti S, Joffre C, Mansat-De Mas V

Abstract excerpt

In acute myeloid leukemia (AML), internal tandem duplication mutations in the FLT3 tyrosine kinase receptor (FLT3-ITD) account for up to 25% of cases and are associated with a poor outcome. In order to better target this AML subtype, a comprehensive view of how FLT3-ITD impacts AML cell biology is required. Here, we found that FLT3-ITD expression increased basal autophagy in AML cells, and that both...

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Share to Activating Transcription Factor 4
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Myeloid, Acute

Share to Mice, Inbred NOD

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Source

Open in PubMed Open full text

Identifiers

PMID: 29059168
DOI: 10.1038/onc.2017.376
PMCID: PMC5808073

Genes

FLT3
ATF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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