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A Drosophila model identifies calpains as modulators of the human leukemogenic fusion protein AML1-ETO

6 Jul 2009

Abstract excerpt

The t(8:21)(q22;q22) translocation is 1 of the most common chromosomal abnormalities linked to acute myeloid leukemia (AML). AML1-ETO, the product of this translocation, fuses the N-terminal portion of the RUNX transcription factor AML1 (also known as RUNX1), including its DNA-binding domain, to the almost entire transcriptional corepressor ETO (also known as MTG8 or RUNX1T1). This fusion protein acts primarily...

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PMID: 19581587
DOI: 10.1073/pnas.0902449106

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