Article

Tumor cell-intrinsic stress states drive sensitivity to CAR T cell-therapy in pancreatic cancer

2025-07-29

Abstract excerpt

Chimeric antigen receptor (CAR) T cell therapy has transformed the treatment of hematologic cancers, but has shown limited efficacy in solid tumors, including pancreatic ductal adenocarcinoma (PDAC). The cellular and molecular factors that influence CAR T cell therapy response remain largely unknown. By integrating modular in vivo CRISPR screens with single cell genomics and immunocompetent orthotopic models of P...

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Identifiers and source

Literature Corpus work: c545131d-3646-59fe-b3b8-f893967f8f14
DOI: 10.1101/2025.07.24.666408

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