Article

Characterization of a pancreatic cancer GWAS signal suggests PDX1 buffers stress in the exocrine pancreas

2026-04-15

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest human cancers. The current largest published PDAC Genome-Wide Association Study (GWAS) identified 23 genetic risk signals, but most lack sufficient characterization. This study aimed to functionally characterize the chr13q12.2 ( PLUT / PDX1 ) PDAC GWAS risk locus. Fine-mapping, luciferase reporter assays, and electrophoretic mobility shift assa...

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Literature Corpus work: 741624bd-f229-58ee-8711-5f53a1ab0fa1
DOI: 10.64898/2026.04.13.26350790

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