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A pancreatic cancer organoid-in-matrix platform shows distinct sensitivities to T cell killing

23 Apr 2024

Abstract excerpt

Abstract Poor treatment responses of pancreatic ductal adenocarcinoma (PDAC) are in large part due to tumor heterogeneity and an immunosuppressive desmoplastic tumor stroma that impacts interactions with cells in the tumor microenvironment (TME). Thus, there is a pressing need for models to probe the contributions of cellular and noncellular crosstalk. Organoids are promising model systems with the potential to...

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PMID: 38654067
DOI: 10.1038/s41598-024-60107-5

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