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A spatial atlas of chemoradiation therapy in pancreatic cancer identifies cellular and microenvironmental determinants of persister populations

2025-06-25

Abstract excerpt

The molecular pathways involved in the response to radiation therapy in pancreatic ductal adenocarcinoma (PDAC) remain poorly understood. We aimed to elucidate the adaptive mechanisms and cellular interactions within PDAC to radiation therapy (RT). We constructed a transcriptomic landscape of the cellular subtypes and spatially resolved neighborhoods from 50 patient samples, including 16 longitudinally matched sin...

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Identifiers and source

Literature Corpus work
3b19152c-3f67-548a-8fd7-28820a7d9130
DOI
10.1101/2025.06.20.660757
Open publication

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A spatial atlas of chemoradiation therapy in pancreatic cancer identifies cellular and microenvironmental determinants of persister populationsDOI 10.1101/2025.06.20.660757
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