Article

Oxidative Stress-Induced Immunogenic Cell Death Enhances Whole-Cell Vaccine Efficacy in a Syngeneic Pancreatic Cancer Model

2026-02-11

Abstract excerpt

<h4>ABSTRACT</h4> Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer, with limited therapeutic options and extremely high mortality rates. While immune checkpoint blockade (ICB) therapy is effective in many types of human cancers, responses in PDAC patients remain poor, partly due to the weak immunogenicity of PDAC tumors. We hypothesized that a whole-cell PDAC vaccine could improve anti-tumor...

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Literature Corpus work: b5b2b939-c8a4-531a-863d-432b72e63616
DOI: 10.64898/2026.02.09.704828

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