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Ongoing Replication Stress Response and New Clonal T Cell Development Discriminate Between Liver and Lung Recurrence Sites and Patient Outcomes in Pancreatic Ductal Adenocarcinoma

2022-05-06

Abstract excerpt

<h4>Background and Aims</h4> Metastatic pancreatic adenocarcinoma (mPDAC) is lethal, yet a subset of patients who have metastatic disease that spreads only to the lung have better outcomes. We identified unique transcriptomic and immune features that distinguish patients who develop metastases in the liver (liver cohort) versus those with lung-avid but liver-averse mPDAC (lung cohort). <h4>Methods</h4> We used c...

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Literature Corpus work
66c38f32-c574-507e-bba6-f492dbafa5cb
DOI
10.1101/2022.05.04.490552
Open publication

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Ongoing Replication Stress Response and New Clonal T Cell Development Discriminate Between Liver and Lung Recurrence Sites and Patient Outcomes in Pancreatic Ductal AdenocarcinomaDOI 10.1101/2022.05.04.490552
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