Article

Uncovering methylation-dependent genetic effects on regulatory element function in diverse genomes

2024-08-24

Abstract excerpt

<h4>ABSTRACT</h4> A major goal in evolutionary biology and biomedicine is to understand the complex interactions between genetic variants, the epigenome, and gene expression. However, the causal relationships between these factors remain poorly understood. mSTARR-seq, a methylation-sensitive massively parallel reporter assay, is capable of identifying methylation-dependent regulatory activity at many thousands of...

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Literature Corpus work: c53a814a-d9b3-5095-8f15-0365263bd43e
DOI: 10.1101/2024.08.23.609412

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