Article

Genome-wide regulatory model from MPRA data predicts functional regions, eQTLs, and GWAS hits

2017-02-20

Abstract excerpt

Massively-parallel reporter assays (MPRA) enable unprecedented opportunities to test for regulatory activity of thousands of regulatory sequences. However, MPRA only assay a subset of the genome thus limiting their applicability for genome-wide functional annotations. To overcome this limitation, we have used existing MPRA datasets to train a machine learning model that uses DNA sequence information, regulatory mo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 91c5baa4-50e1-58db-8cd3-83e20faa704d
DOI: 10.1101/110171

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-wide regulatory model from MPRA data predicts functional regions, eQTLs, and GWAS hitsDOI 10.1101/110171Read

MPRAVarDB: an online database and web server for exploring regulatory effects of genetic variants.Semantic proximity Read

MPRAVarDB: an online database and web server for exploring regulatory effects of genetic variantsSemantic proximity Read

Uncovering methylation-dependent genetic effects on regulatory element function in diverse genomes.Semantic proximity Read

Massively parallel reporter assay–informed modeling improves prediction of context-specific enhancer–gene regulatory interactionsSemantic proximity Read

Meta-analysis of massive parallel reporter assays enables functional regulatory elements predictionSemantic proximity Read

Uncovering methylation-dependent genetic effects on regulatory element function in diverse genomesSemantic proximity Read

Identifying non-coding variant effects at scale via machine learning models of cis-regulatory reporter assaysSemantic proximity Read

Multiple causal variants underlie genetic associations in humans.Semantic proximity Read

A sequence-based global map of regulatory activity for deciphering human geneticsSemantic proximity Read

A semi-supervised model to predict regulatory effects of genetic variants at single nucleotide resolution using massively parallel reporter assays.Semantic proximity Read

An extensive enhancer-promoter map generated by genome-scale analysis of enhancer and gene activity patternsSemantic proximity Read

Direct Identification of Hundreds of Expression-Modulating Variants using a Multiplexed Reporter Assay.Semantic proximity Read