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Article

Uncovering methylation-dependent genetic effects on regulatory element function in diverse genomes.

Genome research - 1 Aug 2025

Petersen Rachel M, Vockley Christopher M, Lea Amanda J

Abstract excerpt

A major goal in evolutionary biology and biomedicine is to understand the complex interactions between genetic variants, the epigenome, and gene expression. However, the causal relationships between these factors remain poorly understood. mSTARR-seq, a methylation-sensitive massively parallel reporter assay, is capable of identifying methylation-dependent regulatory activity at many thousands of genomic regions...

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Topics

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Share to DNA Methylation
Share to Enhancer Elements, Genetic
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Genetic Variation

Share to Genome, Human

Share to Promoter Regions, Genetic

Share to Regulatory Sequences, Nucleic Acid

Source

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Identifiers

PMID: 40659498
DOI: 10.1101/gr.279957.124
PMCID: PMC12315712

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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