Article

A core NRF2 gene set defined through comprehensive transcriptomic analysis predicts selective drug resistance and poor multi-cancer prognosis

2023-04-21

Abstract excerpt

<h4>ABSTRACT</h4> The NRF2-KEAP1 pathway plays an important role in the cellular response to oxidative stress but may also contribute to metabolic changes and drug resistance in cancer. We investigated the activation of NRF2 in human cancers and fibroblast cells through KEAP1 inhibition and cancer associated KEAP1/NRF2 mutations. We define a core set of 14 upregulated NRF2 target genes from seven RNA-Sequencing d...

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Literature Corpus work: f3c5e908-4713-55ac-8b92-fca4882b48b8
DOI: 10.1101/2023.04.20.537691

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