Article

Pan-cancer scale screening reveals NRF2 associated immunoevasive characteristics in non-small cell lung cancer and squamous malignancies

2022-05-15

Abstract excerpt

<h4>Summary</h4> The NRF2 pathway is frequently activated in various cancer types, yet a comprehensive analysis of its effects across different malignancies is currently lacking. We developed a robust NRF2 activity metric and utilized it to conduct a pan-cancer wide analysis of oncogenic NRF2 signaling. We identified a distinct immunoevasive phenotype where high NRF2 activity is associated with low interferon-gam...

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Literature Corpus work: 53835aed-6cab-57be-86ed-435fe2a2f7ca
DOI: 10.1101/2022.05.15.489654

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