Differential KEAP1/NRF2 mediated signaling widens the therapeutic window of redox-targeting drugs in SCLC therapy

Abstract excerpt

Small cell lung cancer (SCLC) patients frequently experience a remarkable response to first-line therapy. Follow up maintenance treatments aim to control residual tumor cells, but generally fail due to cross-resistance, inefficient targeting of tumor vulnerabilities, or dose-limiting toxicity, resulting in relapse and disease progression. Here, we show that SCLC cells, similar to their cells of origin, pulmonary n...

Topics

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• Adenocarcinoma of Lung
• Carcinoma, Non-Small-Cell Lung
• Kelch-Like ECH-Associated Protein 1
• Lung Neoplasms
• Mutation
• NF-E2-Related Factor 2
• Phenotype
• Tumor Microenvironment

Identifiers and source

Literature Corpus work

a21d27e8-0327-545a-b4fb-6b46498a79f5

DOI

10.1101/2024.11.06.621846