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Article

Impacts of NRF2 activation in non-small-cell lung cancer cell lines on extracellular metabolites.

Cancer science - 1 Feb 2020

Saigusa Daisuke, Motoike Ikuko N, Saito Sakae, Zorzi Michael, Aoki Yuichi, Kitamura Hiroshi, Suzuki Mikiko, Katsuoka Fumiki, Ishii Hirofumi, Kinoshita Kengo, Motohashi Hozumi, Yamamoto Masayuki

Abstract excerpt

Aberrant activation of NRF2 is as a critical prognostic factor that drives the malignant progression of various cancers. Cancer cells with persistent NRF2 activation heavily rely on NRF2 activity for therapeutic resistance and aggressive tumorigenic capacity. To clarify the metabolic features of NRF2-activated lung cancers, we conducted targeted metabolomic (T-Met) and global metabolomic (G-Met) analyses of...

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Identifiers

PMID: 31828882
DOI: 10.1111/cas.14278
PMCID: PMC7004536

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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