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Nuclear Factor Erythroid 2-Related Factor 2 in Regulating Cancer Metabolism.

Antioxidants & redox signaling - 1 Nov 2020

Smolková Katarína, Mikó Edit, Kovács Tünde, Leguina-Ruzzi Alberto, Sipos Adrienn, Bai Péter

Abstract excerpt

Significance: Nuclear factor erythroid 2 (NFE2)-related factor 2 (NFE2L2, or NRF2) is a transcription factor predominantly affecting the expression of antioxidant genes. NRF2 plays a significant role in the control of redox balance, which is crucial in cancer cells. NRF2 activation regulates numerous cancer hallmarks, including metabolism, cancer stem cell characteristics, tumor aggressiveness, invasion, and...

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Antioxidants
Energy Metabolism
Hormones
Metabolic Networks and Pathways
Neoplastic Stem Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

NF-E2-Related Factor 2

Oxidation-Reduction

Unfolded Protein Response

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Identifiers

PMID: 31989830
DOI: 10.1089/ars.2020.8024
PMCID: PMC7533893

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