Back to search

Article

Islet-specific DNA hypomethylation identifies gene enhancer loci driving Type 2 Diabetes risk

2025-09-12

Abstract excerpt

<h4>ABSTRACT</h4> Genome-wide association studies (GWAS) have identified hundreds of genetic loci linked to pancreatic islet dysfunction and type 2 diabetes (T2D). Many of these loci map to islet genes and their enhancers; however, a complete understanding of the gene regulatory contributions to T2D is lacking. We have previously shown that cell-type specific DNA hypomethylation patterns identify gene enhancers t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
0855cdbc-a004-5c5e-9d42-27ffbdba8b52
DOI
10.1101/2025.09.09.25335336
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Islet-specific DNA hypomethylation identifies gene enhancer loci driving Type 2 Diabetes riskDOI 10.1101/2025.09.09.25335336
Whole-Genome Bisulfite Sequencing of Human Pancreatic Islets Reveals Novel Differentially Methylated Regions in Type 2 Diabetes PathogenesisSemantic proximity
Genetic regulatory signatures underlying islet gene expression and type 2 diabetes.Semantic proximity
Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility lociSemantic proximity
Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility lociSemantic proximity
Genome-Wide DNA Methylation Analysis of Human Pancreatic Islets from Type 2 Diabetic and Non-Diabetic Donors Identifies Candidate Genes That Influence Insulin SecretionSemantic proximity
Chromatin accessibility profiling uncovers genetic- and T2D disease state-associated changes in <i>cis</i> -regulatory element use in human isletsSemantic proximity
Human pancreatic islet 3D chromatin architecture provides insights into the genetics of type 2 diabetesSemantic proximity
Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetesSemantic proximity
Type 2 Diabetes-Associated Genetic Variants Regulate Chromatin Accessibility in Human Islets.Semantic proximity
Epigenetic landscapes in human pancreatic islets reveal distinct drivers for adaptation to age and type 2 diabetes.Semantic proximity
Pancreatic islet chromatin accessibility and conformation defines distal enhancer networks of type 2 diabetes riskSemantic proximity
Single cell ATAC-seq in human pancreatic islets and deep learning upscaling of rare cells reveals cell-specific type 2 diabetes regulatory signaturesSemantic proximity
Select a neighboring publication to make it the new centre.