Article
eQTL mapping in fetal-like pancreatic progenitor cells reveals early developmental insights into diabetes risk
2021-03-17
Abstract excerpt
The impact of genetic regulatory variation active in early pancreatic development on adult pancreatic disease and traits is not well understood. Here, we generate a panel of 107 fetal-like iPSC-derived pancreatic progenitor cells (iPSC-PPCs) from whole genome-sequenced individuals and identify 4,065 genes and 4,016 isoforms whose expression and/or alternative splicing are affected by regulatory variation. We integ...
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Identifiers and source
- Literature Corpus work
- ba3aa1d0-7d89-5b05-94fd-288abed32661
- DOI
- 10.1101/2021.03.17.435846