Article

Latent plasticity of the human pancreas across development, health, and disease

2025-10-03

Abstract excerpt

The pancreas plays a central role in major human diseases, yet our understanding of its cellular diversity and plasticity remains incomplete. Here, we present a single-cell multiomics atlas of the human pancreas, profiling over four million cells and nuclei from 57 donors across fetal development, adult homeostasis, and type 2 diabetes (T2D). Integrating sc/snRNA-seq, snATAC-seq, VASA-seq, spatial transcriptomics...

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Literature Corpus work: 03bef2f9-7a03-583c-bd94-9011a10e299d
DOI: 10.1101/2025.10.01.679230

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