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Article

Patterns of differential gene expression in a cellular model of human islet development, and relationship to type 2 diabetes predisposition.

Diabetologia - 1 Jul 2018

Perez-Alcantara Marta, Honoré Christian, Wesolowska-Andersen Agata, Gloyn Anna L, McCarthy Mark I, Hansson Mattias, Beer Nicola L, van de Bunt Martijn

Abstract excerpt

AIMS/HYPOTHESIS: Most type 2 diabetes-associated genetic variants identified via genome-wide association studies (GWASs) appear to act via the pancreatic islet. Observed defects in insulin secretion could result from an impact of these variants on islet development and/or the function of mature islets. Most functional studies have focused on the latter, given limitations regarding access to human fetal islet...

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PMID: 29675560
DOI: 10.1007/s00125-018-4612-4
PMCID: PMC6354904

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