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Article

eQTL mapping in fetal-like pancreatic progenitor cells reveals early developmental insights into diabetes risk.

Nature communications - 30 Oct 2023

Nguyen Jennifer P, Arthur Timothy D, Fujita Kyohei, Salgado Bianca M, Donovan Margaret K R, Matsui Hiroko, Kim Ji Hyun, D'Antonio-Chronowska Agnieszka, D'Antonio Matteo, Frazer Kelly A

Abstract excerpt

The impact of genetic regulatory variation active in early pancreatic development on adult pancreatic disease and traits is not well understood. Here, we generate a panel of 107 fetal-like iPSC-derived pancreatic progenitor cells (iPSC-PPCs) from whole genome-sequenced individuals and identify 4065 genes and 4016 isoforms whose expression and/or alternative splicing are affected by regulatory variation. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 37903777
DOI: 10.1038/s41467-023-42560-4
PMCID: PMC10616100

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