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Article

A Chromatin Basis for Cell Lineage and Disease Risk in the Human Pancreas.

Cell systems - 26 Sept 2018

Arda H Efsun, Tsai Jennifer, Rosli Yenny R, Giresi Paul, Bottino Rita, Greenleaf William J, Chang Howard Y, Kim Seung K

Abstract excerpt

Understanding the genomic logic that underlies cellular diversity and developmental potential in the human pancreas will accelerate the growth of cell replacement therapies and reveal genetic risk mechanisms in diabetes. Here, we identified and characterized thousands of chromatin regions governing cell-specific gene regulation in human pancreatic endocrine and exocrine lineages, including islet β cells, α cells,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30145115
DOI: 10.1016/j.cels.2018.07.007
PMCID: PMC6347013

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