Article

Highly Potent Peptide Therapeutics To Prevent Protein Aggregation In Huntington’s Disease

2023-04-28

Abstract excerpt

<h4>ABSTRACT</h4> Huntington’s disease (HD) is a progressive, autosomal dominant neurodegenerative disorder resulting from a significant amplification of CAG repeats in exon 1 of the Huntingtin (Htt) gene. More than 36 CAG repeats result in the formation of mutant Htt (mHtt) protein. These amino-terminal mHtt fragments lead to the formation of misfolded proteins, which then form aggregates in relevant brain regio...

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Literature Corpus work: cab8d68e-1b49-591f-8900-aa044f2f7e16
DOI: 10.1101/2023.04.27.538016

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