Article

Search for the elusive haplotype of the APOE polymorphism associated with Alzheimer’s disease

2024-09-26

Abstract excerpt

<title>Abstract</title> <p>The common <italic>APOE2/E3/E4</italic> polymorphism is determined by two-site haplotypes: C112R and R158C. Due to strong linkage disequilibrium between the two sites, three of the four expected haplotypes/alleles (<italic>E2, E3, E4</italic>) have been observed. Compared to the most common haplotype of <italic>E3</italic> (C112 – R158), the <italic>E4</italic> (R112 – R158) and <italic...

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Literature Corpus work: d8e5c425-1d0b-5eea-b31b-3be5f967cb27
DOI: 10.21203/rs.3.rs-4902566/v1

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