Article

Human APOE variants in Alzheimer’s Disease and type III hyperlipoproteinemia: insights from Long-Evans knock-in rat models with humanized App and APOE

2024-08-21

Abstract excerpt

<title>Abstract</title> <p>APOE is a major genetic factor in late-onset Alzheimer's disease (LOAD), with APOE4 significantly increasing risk, APOE3 acting as a neutral isoform, and APOE2 offering protective effects. The primary hypothesis links APOE isoforms to LOAD through their impact on Aβ production and deposition, which is thought to be related to their effects on lipid metabolism. Specifically, APOE4 enhanc...

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Literature Corpus work: c4cbd78c-d9f0-59d0-b5f4-13d17a8498d0
DOI: 10.21203/rs.3.rs-4789248/v1

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