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Proteomic Analysis of Huntington’s Disease Medium Spiny Neurons Identifies Alterations in Lipid Droplets

2022-05-11

Abstract excerpt

<h4>ABSTRACT</h4> Huntington’s disease (HD) is a neurodegenerative disease caused by a CAG repeat expansion in the Huntingtin ( HTT ) gene. The resulting polyglutamine (polyQ) tract alters the function of the HTT protein. Although HTT is expressed in different tissues, the medium spiny projection neurons (MSNs) in the striatum are particularly vulnerable in HD. Thus, we sought to define the proteome of human HD...

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Literature Corpus work
c4a0a131-ab65-5158-b33c-be52c62574e4
DOI
10.1101/2022.05.11.491152
Open publication

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Proteomic Analysis of Huntington’s Disease Medium Spiny Neurons Identifies Alterations in Lipid DropletsDOI 10.1101/2022.05.11.491152
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