Article

Defective mitochondrial-lysosomal axis promotes extracellular vesicles release of mitochondrial components in Huntington’s Disease

2022-02-13

Abstract excerpt

<h4>ABSTRACT</h4> Mitochondrial and autophagy dysfunction are mechanisms proposed to be involved in the pathogenesis of several neurodegenerative diseases. Huntington’s disease (HD) is a progressive neurodegenerative disorder associated with mutant Huntingtin-induced abnormalities in neuronal mitochondrial dynamics and quality control. Former studies suggest that the removal of defective mitochondria may be compr...

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Literature Corpus work: 128905a4-3d7b-574a-9fe5-e3f9f4df0357
DOI: 10.1101/2022.02.13.480262

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