Article

Chronic central-targeted Interleukin-6 overexpression promotes hippocampal and cortical neuropathology in the Tg2576 mouse model of Alzheimer’s disease

2025-02-08

Abstract excerpt

<h4>Summary</h4> Interleukin-6 (IL-6) is a cytokine detected in the brains and peripheral fluids of both Alzheimer’s disease (AD) patients and mouse models, where it colocalizes with amyloid-beta (Aβ) levels and amyloid plaques. Interestingly, IL-6 deficiency ameliorates cognitive deficits and attenuates hippocampal neuroinflammation, whereas astrocyte-targeted IL-6 signaling via its soluble receptor accentuates...

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Literature Corpus work: c4942e26-47fb-5e35-88a3-c6c6d590bce1
DOI: 10.1101/2025.02.06.636831

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