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Article

Structural and Functional Impact of the Transgenic Expression of Cytokines in the CNSa

1 May 1998

Abstract excerpt

Cytokines are powerful mediators of biologic responses in the CNS and may contribute to cellular injury in pathophysiologic states. In order to better understand the actions of cytokines in the intact mammalian CNS, a transgenic approach was employed that targeted the expression of different cytokines to astrocytes in mice. Fusion gene constructs consisting of a GFAP expression vector into which was inserted the...

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PMID: 9629240
DOI: 10.1111/j.1749-6632.1998.tb09552.x

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