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Article

Chronic exposure to IL-6 induces a desensitized phenotype of the microglia.

Journal of neuroinflammation - 22 Jan 2021

Recasens Mireia, Almolda Beatriz, Pérez-Clausell Jeús, Campbell Iain L, González Berta, Castellano Bernardo

Abstract excerpt

BACKGROUND: When the homeostasis of the central nervous system (CNS) is altered, microglial cells become activated displaying a wide range of phenotypes that depend on the specific site, the nature of the activator, and particularly the microenvironment generated by the lesion. Cytokines are important signals involved in the modulation of the molecular microenvironment and hence play a pivotal role in...

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Identifiers

PMID: 33482848
DOI: 10.1186/s12974-020-02063-1
PMCID: PMC7821504

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