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Article

An electrostatic cluster guides Aβ40 fibril formation in sporadic and Dutch-type cerebral amyloid angiopathy.

Journal of structural biology - 1 Jun 2024

Fu Ziao, Crooks Elliot J, Irizarry Brandon A, Zhu Xiaoyue, Chowdhury Saikat, Van Nostrand William E, Smith Steven O

Abstract excerpt

Cerebral amyloid angiopathy (CAA) is associated with the accumulation of fibrillar Aβ peptides upon and within the cerebral vasculature, which leads to loss of vascular integrity and contributes to disease progression in Alzheimer's disease (AD). We investigate the structure of human-derived Aβ40 fibrils obtained from patients diagnosed with sporadic or familial Dutch-type (E22Q) CAA. Using cryo-EM, two primary...

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Identifiers

PMID: 38615725
DOI: 10.1016/j.jsb.2024.108092
PMCID: PMC11162928

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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