Article

An electrostatic cluster guides Aβ40 fibril formation in cerebral amyloid angiopathy

2022-12-22

Abstract excerpt

<h4>ABSTRACT</h4> Cerebral amyloid angiopathy (CAA) is associated with the accumulation of fibrillar Aβ peptides upon and within the cerebral vasculature, which leads to loss of vascular integrity and contributes to disease progression in Alzheimer’s disease (AD). We investigate the structure of human-derived Aβ40 fibrils obtained from patients diagnosed with sporadic or familial Dutch-type (E22Q) CAA. Using cryo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cb01a2bc-dea5-586f-870b-d12cddec4d88
DOI: 10.1101/2022.12.22.521588

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An electrostatic cluster guides Aβ40 fibril formation in cerebral amyloid angiopathyDOI 10.1101/2022.12.22.521588Read

An electrostatic cluster guides Aβ40 fibril formation in sporadic and Dutch-type cerebral amyloid angiopathy.Semantic proximity Read

Cryo-EM Structures of Amyloid-β Filaments With the Arctic Mutation (E22G) From Human and Mouse BrainsSemantic proximity Read

Intermediate antiparallel fibrils in Aβ40 Dutch mutant aggregation: nanoscale insights from AFM-IRSemantic proximity Read

Intermediate Antiparallel Fibrils in Aβ40 Dutch Mutant Aggregation: Insights from Nanoscale Infrared Spectroscopy.Semantic proximity Read

The in-tissue molecular architecture of β-amyloid in the mammalian brainSemantic proximity Read

Distinct amyloid-β filament fold in individuals with APP Flemish mutation.Semantic proximity Read

Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains.Semantic proximity Read

E22G Aβ40 fibril structure and kinetics illuminate how Aβ40 rather than Aβ42 triggers familial Alzheimer's.Semantic proximity Read

Cryo-EM reveals structural variability of apolipoprotein A-I amyloid fibrils across organs, mutations, and clinical presentations.Semantic proximity Read

Structural variability of apolipoprotein A-I amyloid fibrils across organs, mutations, and clinical presentations, revealed by cryo-EMSemantic proximity Read

The in-tissue molecular architecture of β-amyloid pathology in the mammalian brain.Semantic proximity Read

Molecular basis for amyloid-β polymorphismSemantic proximity Read