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Engineering Tripartite Gene Editing Machinery for Highly Efficient Non-Viral Targeted Genome Integration

2023-10-23

Abstract excerpt

<title>Abstract</title> <p>Non-viral DNA donor template has been widely used for targeted genomic integration by homologous recombination (HR). This process has become more efficient with RNA guided endonuclease editor system such as CRISPR/Cas9. Circular single stranded DNA (cssDNA) has been harnessed previously as a genome engineering catalyst (GATALYST) for efficient and safe targeted gene knock-in. Here we de...

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Literature Corpus work: c46a6960-6c27-57c0-aa03-46bde998180f
DOI: 10.21203/rs.3.rs-3365585/v1

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